LC Scientific
LC Scientific
Beyond Formaldehyde
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Advancing protein–DNA interaction mapping through next-generation crosslinking technology.
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LC Scientific is developing BFPX, a photoactivated crosslinking technology designed to improve the capture of challenging transcription factor–DNA interactions for ChIP-seq and related genomic applications.
Protein-DNA interactions can be difficult to capture
Protein-DNA interactions can be difficult to capture
Formaldehyde has enabled decades of chromatin research, but crosslinking efficiency can vary substantially across transcription factors and protein–DNA interactions. As a result, some biologically important targets remain difficult to study by conventional ChIP-seq.
BFPX provides an alternative crosslinking strategy designed for these challenging interactions.
BFPX Technology
BFPX Technology
BFPX uses a DNA-intercalating probe and controlled photoactivation to stabilize transcription factor–DNA interactions through covalent crosslinking.
BFPX-ChIP Services
BFPX-ChIP Services
We work with researchers studying transcription factors that have produced weak, inconsistent, or failed results with conventional ChIP-seq approaches.
Project-specific evaluation of challenging transcription factor targets
BFPX-ChIP-seq performed using conditions tailored to the target and experimental system
Sequencing and core data delivery, with additional analysis available for selected projects
Scientific support from initial consultation through project completion
Example of improved capture with BFPX
Have a transcription factor that has been difficult to study by ChIP?
Have a transcription factor that has been difficult to study by ChIP?
Let’s discuss your target, experimental system, and project goals.
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